In our experience, most people don’t use samplers only for playing sampled versions of “real” instruments. Very often, single “stand alone” or single samples are used. Maybe you wish to use different sounds for every key zone. Or you could have complete chorus and verse vocals plus variations assigned to several “one note” key zones. Or use samples of different chords that play rhythmic figures to the same tempo, and use these to build song structures etc. The possibilities are endless. When you use samples in this way, the keys on your keyboard that play the samples do not necessarily correspond to pitch at all, the keys are simply used to trigger the samples.