In this text we refer to Reason Essentials as a ReWire slave and the application receiving audio from Reason Essentials (this could be Steinberg Cubase, Apple Logic Audio or MOTU Digital Performer, for example) as the host application.
To run Reason Essentials together with another audio application of course raises the demands on computing power. However, adding ReWire to the equation does not in itself require a more powerful computer. On the contrary, it is likely that ReWiring two programs requires less power than, for example, running them with one audio card each.
All synchronization to other equipment is handled from the host application - not in Reason Essentials. In fact there are no special synchronization issues. All that is said in the host application’s documentation about synchronizing audio channels is true for ReWire channels as well.